Lipid Excepients

Description

 

The use of lipids in sustained release formulations is growing. The use of lipid-based dosage forms for enhancement of drug absorption or delivery has drawn considerable interest from pharmaceutical scientists. The unique characteristics of these dosage forms, however, present significant challenges to pharmaceutical industry and regulatory agencies in many ways. Lipid excipients delivery the drug by creating an insoluble matrix structure from which diffusion is the principal drug release mechanism. It not only forms a water-insoluble matrix, but provides pH-independent release, non-digestible, highly resistant to physiological conditions, and does not result in alcohol-related dose dumping.

Solubilizer, Bioavailability enhancer, Co-solvent in capsule filling, Inhalation products, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid etc.

 

Tablet Lubricant, Lipid Matrix for Sustained Release, Coating for Protection and Taste Masking. Oral Solid Dosage forms in Direct Compression, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, Spheronization, Supercritical Fluid Extract etc.

Semi-solid vehicle, Non-ionic thickener for emulsions

 

Major Raw Materials

 

Glycerol, caprylic acid, capric acid (C 8 -C 10 ) & Solid acid catalyst

 

Brief Process Description

 

This is an import substitute. Process for the preparation of Lipid excipient involves the esterification of glycerol with C 8 -C 10 fatty acid mixture employing solid acid catalyst. The product meets the International standard specifications

 

Scale of Demonstration

 

100 g of Glycerol/batch

 

Status of Commercialization

 

Looking forward for industry collaboration for upscaling.

For further information please contact

 

CSIR-Indian Institute of Chemical Technology
Uppal Road, Tarnaka,
Hyderabad - 500 007
Phone: +91-40-21791623
E-mail: aau@iict.res.in