Celecoxib (Flow Process)

Description

 

It is a nonsteroidal anti-inflammatory drug and specifically a COX-2 inhibitor. Used for relieving pain and inflammation. Also used in treating arthritis.

 

IPR Status

 

• Application submitted to CSIR for filing Indian patent.   Ref. No.   0163NF2018.

 

Salient Technical Features

 

CSIR-IICT has developed the flow process for celecoxib. The process involves condensation of diketone and 4-hydrazinylbenzenesulfonamide hydrochloride in a combination of methanol and water as a solvent system to synthesize celecoxib with a yield of 85% after quenching, separation and purification

 

Scale of Development

•  CSIR-IICT has developed the continuous flow process for celecoxib at 1.54 mmol h –1 . (3 g per 12 h with the existing units).

 

Status of Commercialization

 

•  Process is ready for demo and can be scaled up for commercial plant

 

Major Raw Materials to be Utilized

 

•  4,4,4-trifluoro-1-( p -tolyl)butane-1,3-dione and 4-hydrazinylbenzenesulfonamide hydrochloride.

 

Major Plant Equipment and Machinery Required

 

•  High pressure pumps, Heater, Back pressure regulator (BPR), Extractor, Separator

For further information please contact

 

CSIR-Indian Institute of Chemical Technology
Uppal Road, Tarnaka,
Hyderabad - 500 007
Phone: +91-40-21791623
E-mail: aau@iict.res.in