Nimbatiktam for The treatment of Psoriasis

Introduction

The Central Council for Ayurveda & Siddha, under Ministry of Health & Family Welfare has developed the technology for above preparation.

Psoriasis is a chronic, recurrent papulo-squamous dermatosis with silvery grey scaling papules of plaques. It is a commonly occurring condition and constitutes 2-4 percent of all cases of skin diseases One of the active principles Nimbidin isolated from the oil of Malia azadirachta Melia azadirachta Linn (Nimba), a common drug widely used in various types of skin diseases in Ayurveda. A bitter solid isolate (nimbatiktam) was studied clinically on diagnosed cases of psoriasis. The drug was administered in capsule form twice a day for 60 days. There was significant improvement in symptoms like etiching, roughness, exfoliation etc. about 87% of the patients got relieved from all these symptoms

Clinical Trials

Patient with well-defined psoriatic lesions with no complications was taken for clinical trial. A daily intake of about 2400 calories containing of non-vegetarian diet rich in proteins is provided.

Necessary laboratory investigations including routine blood examinations like TC, DC, ESR, Biochemical examinations, L.F.T. skin biopsy were carried out besides having photographs of the case at different stages.

• Age below 15 years and above 60 years.
• Typical distribution of the Psoriatic lesions

Criteria for assessment and diagnosis

• Typical distribution of the Psoriatic lesions
• Well defined non-indurated, dry erythematous area with silvery layer scaling (30% of body surface involvement)
• The candle grease sign.
• Positive histopathological findings.

Process

Using the bitter solid isolate nimbatiktam capsule are prepared by mixing the ingredient. The powder is filled in the capsules. The active principle is maintained as 200 mg. per capsule.

Plant Parameters

Capacity :(Capsules / Year): 10 million
No.of Shifts / day : 2
Working days / Yr : 300
Land Area, m2 : 600
Covered Area, m2 : 200

Manpower

Managerial : 1
Skilled : 10
Unskilled : 15

Economics

Plant & Machinery: Rs. 10,00,000
Know-how Fees : Rs. 3,00,000
Recurring Royalty : 4 % on sales
Licence Period : 10 Years
Nature of Licence : Non exclusive
*The above figures are for budgetary purposes only and subject to change in subsequent offers

For further information please contact

Asian and Pacific Centre for Transfer of Technology,
APCTT Building,
C-2 Qutab Institutional Area,
P.O.Box - 4575
New Delhi - 110 016
India