Process for The Synthesis of Highly Functionalized Racemic and Non-Racemic Piperidines

Introduction

The technology offers a single-pot two-step process for synthesis of highly functionalized piperidines in stereochemically pure forms. Synthesis of 2,6- disubstituted piperidines in diastereo as well as enantiopure forms involves simple precursors like substituted 1,3-dicarbonyl compounds and imines. The process involves a domino-imino-aldol-aza-Michael reaction sequences . The process has been developed at the Chemistry Department of Indian Institute of Technology, Kanpur.

Applications

•  Synthesis of piperidine ring systems

•  Synthesis of drugs with piperidine ring system

Competitive Advantages

•  The two steps are executed sequentially in a single pot operation

•  Better chemical yield than current multistep processes

•  Stereo selectivity of the final product easily controlled by varying reaction parameters.

•  Avoids use of any hazardous or toxic material.

•  No requirement of isolating intermediate products

•  Requires fewer reagents

State of Development

The technology is developed and validated till lab scale.

Licensing Opportunity

BCIL is looking for a suitable company involved in production of pharmaceutical drugs.

For further information please contact

Biotech Consortium India Limited

V Floor, Anuvrat Bhawan

210, Deen Dayal Upadhay Marg

New Delhi-110002

Phone: +91 (011) 23219064-67