Process for Preparation of Chiral Gammalactams

Introduction

The technology offers a novel and efficient single step process of synthesizing highly functionalized chiral gamma-lactam bearing three contiguous stereocenters, in diastereomerically and enantiomerically pure form. The process has been developed at the Chemistry Department of Indian Institute of Technology, Kanpur.

Applications

•  Synthesis of functional core of drugs.

•  Synthesis of drugs based on chiral GABA scaffold (e.g. Pregabalin (Lyrica).

•  Synthesis of drug like molecules which have γ-lactam core.

Competitive Advantages

•  Single step process

•  Enantioselective synthesis of both the enantomers of the products just by altering the chirality of the substrates

•  Avoids tedious process of separation of enantiomers

•  Utilises starting materials which can be easily synthesised

•  The process provides quantitative chemical yields up to > 99% of the products with almost enantiospecificity ee > 99%.

•  The product shows anitubercular activity

•  Avoids use of any hazardous or toxic material.

•  Process is low cost and takes less time for synthesis

Licensing Opportunity

BCIL is looking for a suitable company involved in production of pharmaceutical compounds.

For further information please contact

Biotech Consortium India Limited

V Floor, Anuvrat Bhawan

210, Deen Dayal Upadhay Marg

New Delhi-110002

Phone: +91 (011) 23219064-67