Improved Antimicrobial Nylon Sutures and Products Thereof

Introduction

Surgical sutures, particularly of non-absorbable type shall possess good biocompatible and antimicrobial properties. These are made of either natural or synthetic material. From the end usage requirement, the base material should have better strength and elasticity, ease for handling as well as more affinity to the coating material. Further, the delivery of antimicrobial agent shall be slow initially and sustained for longer duration for improving the healing process by eliminating the danger of infection and inflammation. Since the presently available sutures does not have all these quality requirements together, an inherently atimicrobial and biocompatible drug delivery nylon suture has been developed. These sutures have wider application also.

Description

Saturated solution of poly-N-vinyl-pyrrolidinone-iodine complex is prepared in a low boiling solvent. Nylon chips are reacted with this solution for obtaining homogeneous coating of the solution on the chips. The chips are subsequently dried and subjected to spinning to draw a filament, preferably a mano-filament. Drawing multi-filaments is avoided since they are prone to transmission of bacteria through the hidden areas in such filaments. To enhance the strength of the filament, it is drawn at the prescribed temperature with a particular force. The suture prepared as per the above procedure, have polar bonding between nylon and poly-N-vinyl-pyrrolidinone-iodine complex, which results in the slow and controlled release of iodine from the sutures. Also they have demonstrated inherent microbial properties in addition to being biocompatible.

Special Features

Inherently antimicrobial and biocompatible suture which enables to stop the growth of microbes right at the first step; Release of Iodine is initially slow and increase sharply and then levels-off for a longer duration, making the suture suitable for wider application; Does not cause side effects; Improved strength and elasticity as well as knot security; Easy handling and cost effective

Prospective Users

All hospitals and Nursing homes involved in minor and major surgical operation

Keywords

Sutures, Antimicrobial, Nylon, Biocompatible

Status of IPR Protection

Indian Patent Application No. 3032/DEL/98 dated 13.10.1999 having title ' A Method for preparation of Improved Antimicrobial Nylon Sutures and Products thereof'

Major Equipment & Facilities required

Extruder, Drawing unit, Reaction vessels, drier, etc. at a total estimated cost of 15 lakhs. appr

Requirement of Raw Materials/Components

• Polypropylene
• Poly-N-vinyl-pyrrolidinone-iodine
• Acetone

Developed by : Prof. Harpal Singh
Department: Center for Biomedical Engineering

For further information please contact

Managing Director
Foundation for Innovation and Technology Transfer (FITT)
Indian Institute of Technology, Delhi
Hauz Khas, New Delhi-110016, INDIA
Tel : 91-011-26597167, 26857762, 26581013, 26597153
Fax : 91-011-26851169
E-mail : drkdpn@gmail.com