Development of Kits for Isolation of Adipocyte-Derived Stem Cells for Prolotherapy and Other Regenerative Medicine

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Introduction


A simple device, safe and closed system kind (single-use) to isolate stromal vascular fraction (SVF) rich in stem cells from adipose tissue for autologous stem cell based therapies. The device is a single tube with multiple ports for tissue lipoaspirate intake, washing with buffers, enzyme digestion and collection of cellular population with two filters (40u and 6u). The device will be set in a semi-automated centrifuge with mixer, incubator and a vacuum pump to aspirate out waste.

 

Stage of Development

 

Proof of Concept.

 

Unique Features of The Product/Technology

 

The device will be an indigenous and affordable to use product with multiple applications like orthopaedics/dermatology/skin regeneration/wound-healing/diabetes/kidney-failure etc. The device can be used for autologous and allogeneic stem cell therapies with a minimum essential requirement included an incubator and a centrifuge for usage.

 

Market Potential

 

Presently stem cell related global market is in billions of dollars. Stempeutics in India is working on a fully automated device called Stempeutron. The proposed product will be cheaper and cost effective. The device is at an estimate of 3500-5000 INR as of now.

 

National/Societal Relevance

 

Currently adipose tissue is in use for various cosmetology purposes, the fat is being isolated and treated manually before injecting back into the patient which causes necrosis in several cases. Mixing stem cells from fat along with lipofillers can enhance the efficacy. Clinical trials in US and other countries are under-way for osteoarthritis and similar ailments.

 

For further information please contact

 

Biotechnology Industry Research Assistance Council (BIRAC)

1 st Floor, MTNL Building, 9, CGO Complex,

Lodhi Road, New Delhi- 110003

Phone: +91-11- 24389611

Email- birac.dbt@nic.in