Demonstration of Conversion of Benzaldehyde to Phenylacetylcarbinol (PAC) with Improved Efficiency on Scale of 4 KL

Introduction

DPRDP Program at IITB resulted in genetic engineering at the allosteric site of enzyme PDC, such that the catalytic site remains open. This resulted in lower Km value of enzyme for pyruvate .

State of Development

Pre-commercialization

Unique Features of the Product/Technology

1. In-vitro property decrease in Km value of enzyme could be translated into in vivo effects, resulting in substantial conservation of feedstock molasses

2. Innovations done successfully in downstream and utility to facilitate commercial viability

3. Scaleup done with QbD in place and minimisation of impact of input variations established

Market Potential

Embio is second largest producer of R-PAC related APIs and exports to 24 countries. The innovator in BASF Germany, who is on verge of exiting this business. This superior technology could accelerate this exit and give Embio a bigger market share .

For further information please contact :  

Biotechnology Industry Research Assistance Council (BIRAC)
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