Nano-engineered bioresorbable polymer-composite for bone-soft tissue fixation applications. (nano-composition)

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Technology Description


The present invention provides a novel biodegradable, biocompatible, bioactive nano-composites as orthopedic biomaterials. The composition may be used to make orthopedic devices to cater fixation of soft tissue injuries, small bone fractures, fractures in paediatrics, etc. The present composite material is desirable because it allows bone tissue proliferation, supports vascularization and is biocompatible and resorbable. Composition described in the present invention is preferably composed of blend of biodegradable polymer such as poly-ε-caprolactone (PCL), natural fiber silk fibroin and an osteoconductive component like Magnesium oxide (MgO) in nanoparticle form, later two as filler. Biomaterial composition in present invention contains FDA-approved biodegradable biocompatible polymer PCL. The mechanical, thermal and degradation properties can be tailored by its reinforcement with FDA-approved natural fiber silk fibroin extracted from Bombyx mori. MgO nanoparticles are proven as an antibacterial agent against Gram negative bacteria like Pseudomonas aeruginosa etc. and Gram positive bacteria viz. Staphylococcus aureus, which are profoundly found at the site of implant-related infections. MgO nanoparticles have also been employed as bioactive filler, reinforcement in biodegradable polymer-composites serving as biomaterials for orthopedic applications. The aspect of the present invention is manufacture of orthopedic devices especially implantable like screws, suture anchors, pins, wires, staples, tacks, arrows, washers, plates, etc. from the above described composite biomaterial. It provides affordable solution to unmet nee.


Institution: IIT


Category : Nano Composition


Cost effective : Yes


In vivo studies : under process


Life of Patent : Not yet granted


Validation : Yes


Prototype: Yes


Public health relevance : Yes- Nano composite used to indigenously manufacture bone-soft tissue fixation devices


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